About her[]
Francine arrived at Springfield Elementary as a new student and was initially believed to be very shy and withdrawn. However, upon Lisa attempting to befriend her, she unveils her true colors as beat by socking Lisa in the eye.
After several failed attempts by Lisa to befriend Francine, instead she made an enemy, she became the subject of Lisa's science experiment on the motivations of bullies, especially after Francine made absolutely no attempt at bullying her during swim class.
The experiment revealed that bullies threaten and pick on nerds because of a pheromone they emit, which Lisa dubs "poindextrous."
During Lisa's presentation, Francine was initially pacified by "bully repellent" (salad dressing), but then went on a nerd beating rampage at The Big Science Thing when Lisa discovers she has run out of repellent.
Francine's parents (who helped with the caging for the experiment) assure the Simpsons that "she will punch herself out eventually."
In the game[]
She was facing the other direction where there were red lines on both sides, and Lisa sprayed herself with perfume so she could safely pass to get the duct tape.